Both Resat and Resol depend on the

Both Re
sat and Re
sol depend on the length and unsaturation
of the hydrophobic chains, as well as the phase
transition and temperature (Table 1). Abundant data
are available on the effect of temperature on the solubilization
of fluid, or liquid-crystalline, bilayers. The results of
these studies [17,46,47] are key to understanding the
effects of other factors. For instance, the detergent concentration
required to solubilize liquid-crystalline
bilayers increases on heating of the system. In comparison
to the differences between gel and liquid-crystalline
bilayers, the change due to heating of liquid-crystalline
liposomes is small but reproducible.
Our interpretation of these results is based on the
assumption that the concentration of detergent required
for solubilization increases with the difference in curvature
between the two amphiphiles. Hence, on heating-induced
expansion of the phospholipid hydrocarbon moiety relative